publications
Article
Association of LRP5 genotypes with osteoporosis in Tunisian post-menopausal women  |
BEN AMMAR GAIED Amel, Sahli Hela, Sassi Rim, Sellami Slaheddine, Souissi Chiraz, 2014 |
BioMed Central Musculoskeletal Disorders, 15, 144, 1-6, Avril 2014 |
Résumé
Background: Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density
(BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified in
Caucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known.
Methods: To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in North
Africans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7.7 years,
of which 59.1% have low bone mass (T-score < −1 at spine or hip).
Results: In post-menopausal Tunisian women, 1330Val was weakly associated with reduced BMD T-score at lumbar
spine (p = 0.047) but not femur neck. Moreover, the TT/TC genotypes tended to be more frequent in women with
osteopenia and osteoporosis than in women with normal BMD (p = 0.066). Adjusting for body size and other
potential confounders, LRP5 genotypes were no longer significantly associated with aBMD at any site.
Conclusions: The less common Val667Met polymorphism showed no association with osteoporosis. The
Ala1330Val polymorphism is weakly associated with lower lumbar spine bone density and osteopenia/osteoporosis
in postmenopausal Tunisian women. These observations expand our knowledge about the contribution of LRP5
genetic variation to osteoporosis risk in populations of diverse ethnic origin.
Background: Osteoporosis is a highly heritable trait. Among the genes associated with bone mineral density(BMD), the low-density lipoprotein receptor-related protein 5 gene (LRP5) has been consistently identified inCaucasians. However LRP5 contribution to osteoporosis in populations of other ethnicities remains poorly known.
Methods: To determine whether LRP5 polymorphisms Ala1330Val and Val667Met are associated with BMD in NorthAfricans, these genotypes were analyzed in 566 post-menopausal Tunisian women with mean age of 59.5 ± 7.7 years,of which 59.1% have low bone mass (T-score < −1 at spine or hip).
Results: In post-menopausal Tunisian women, 1330Val was weakly associated with reduced BMD T-score at lumbarspine (p = 0
