publications
Article
Plasma arachidonic and docosahexaenoic acids in Tunisian very low birth weight infants: status and association with selected neonatal morbidities |
Fares Samira, FEKI Moncef, KAABACHI Naziha, Sethom Mohamed Marouen, 2015 |
Journal of Health, Population and Nutrition, 33:1, (2015) 33:1, 1-6, Juin 2015 |
Résumé
To study plasma arachidonic acid (AA) and docosahexaenoic acid (DHA) status in Tunisian very low birth weight
(VLBW) infants and their association with selected neonatal morbidities. A total of 709 VLBW infants and 339 term
infants were included. Plasma fatty acids were analyzed using capillary gas chromatography. VLBW infants had
significantly (p < 0.001) lower plasma AA (9.44 ± 2.12 vs. 10.8 ± 2.10) and DHA (2.56 ± 0.89 vs. 3.46 ± 1.09) levels, but
higher n-6:n-3 ratio (5.58 ± 1.22 vs. 5.17 ± 1.46) than term infants. In VLBW infants, plasma AA and DHA were related
to gestational age (r = 0.156; p = 0.001 and r = 0.134; p = 0.003, respectively), birthweight (r = 0.242; p < 0.001 and
r = 0.181; p < 0.001, respectively) and head circumference (r = 0.138; p = 0.005 and r = 0.108; p = 0.027, respectively).
Infants with respiratory distress syndrome have decreased plasma AA and DHA and those with intraventricular
hemorrhage have decreased plasma AA and n-6:n-3 ratio. Sepsis was associated with decreased DHA levels. Plasma
long chain polyunsaturated fatty acids status is low in VLBW infants. These deficits may enhance the risk of common
neonatal morbidities, rendering their prevention and correction greatly warranted
To study plasma arachidonic acid (AA) and docosahexaenoic acid (DHA) status in Tunisian very low birth weight(VLBW) infants and their association with selected neonatal morbidities. A total of 709 VLBW infants and 339 terminfants were included. Plasma fatty acids were analyzed using capillary gas chromatography. VLBW infants hadsignificantly (p < 0.001) lower plasma AA (9.44 ± 2.12 vs. 10.8 ± 2.10) and DHA (2.56 ± 0.89 vs. 3.46 ± 1.09) levels, buthigher n-6:n-3 ratio (5.58 ± 1.22 vs. 5.17 ± 1.46) than term infants. In VLBW infants, plasma AA and DHA were relatedto gestational age (r = 0.156; p = 0.001 and r = 0.134; p = 0.003, respectively), birthweight (r = 0.242; p < 0.001 andr = 0.181; p < 0.001, respectively) and head circumference (r = 0.138; p = 0.005 and r = 0.108; p = 0.027, respectively).Infants with respiratory distress syndrome have decreased plasma AA and DHA and those with intraventricularhemorrhage have decreased plasma AA and n-6:n-3 ratio. Sepsis was associated with decreased DHA levels. Plasmalong chain polyunsaturated fatty acids status is low in VLBW infants. These deficits may enhance the risk of commonneonatal morbidities, rendering their prevention and correction greatly warranted
